Discovery Platform

Publications

“Dimeric Macrocyclic Antagonists of Inhibitor of Apoptosis Proteins for the Treatment of Cancer”

Yong Zhang, Benjamin A. Seigal, Nicholas K. Terrett, Randy L. Talbott, Joseph Fargnoli, Joseph G. Naglich, Charu Chaudhry, Shana L. Posy, Ragini Vuppugalla, Georgia Cornelius, Ming Lei, Chunlei Wang, Yingru Zhang, Robert J. Schmidt, Donna D. Wei, Michael M. Miller, Martin P. Allen, Ling Li, Percy H. Carter, Gregory D. Vite, and Robert M. Borzilleri
ACS Medicinal Chemistry Letter, 2015, 6, 770–775

“DNA-Encoded Chemical Libraries of Macrocycles”

William H. Connors, Stephen P. Hale and Nicholas K. Terrett
Current Opinion in Chemical Biology, 2015, 26, 42–47

“The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity”

Benjamin A. Seigal, William H. Connors, Andrew Fraley, Robert M. Borzilleri, Percy H. Carter, Stuart L. Emanuel, Joseph Fargnoli, Kyoung Kim, Ming Lei, Joseph G. Naglich, Matthew E. Pokross, Shana L. Posy, Henry Shen, Neha Surti, Randy Talbott, Yong Zhang, and Nicholas K. Terrett
Journal of Medicinal Chemistry, 2015, 58, 2855–2861

“Screening Large Compound Collections”

Stephen P. Hale
A Handbook for DNA-Encoded Chemistry, Wiley, 2014, 281-318

“Drugs in Middle Space”

Nicholas K. Terrett
MedChemComm, 2013, 4, 474-475

“Drug Discovery Beyond the Rule of 5: Methods for the Synthesis of Macrocycle Libraries for Drug Discovery”

Nicholas K.Terrett
Drug Discoveries Today: Technologies, 2010, 7, 97-104

“Macrocycles for Drug Discovery – An Underexploited Structural Class”

Edward Driggers, Stephen Hale, Jinbo Lee and Nicholas Terrett
Nature Reviews Drug Discovery, 2008, 7, 608-624 (PDF)

“Diamine Catalyzed Hemicyanine Dye Formation from Nonfluorescent Precursors through DNA Programmed Chemistry”

Yumei Huang and James Coull
Journal of the American Chemical Society, 2008, 130, 3238–3239.

 

David Liu’s Laboratory Publications

For a description of DNA-Templated Organic Synthesis (DTS) and a full publication list with downloadable papers, go to the Liu Harvard University Laboratory website evolve.harvard.edu

“Translation of DNA into a Library of 13,000 Synthetic Small-Molecule Macrocycles Suitable for In Vitro Selection”

Brian N. Tse, Thomas M. Snyder, Yinghua Shen, and David R. Liu
Journal of the American Chemical Society, 2008, 130, 15611-15626

“Small-Molecule Diversification from Iterated Branching Reaction Pathways Enabled by DNA-Templated Synthesis”

Christopher T. Calderone and David R. Liu
Angewandte Chemie International Edition, 2005, 44, 7383-7386

“Ordered Multistep Synthesis in a Single Solution Directed by DNA Templates”

Thomas M. Snyder and David R. Liu
Angewandte Chemie International Edition, 2005, 44, 7379-7382

“DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles”

Zev J. Gartner, Brian N. Tse, Rozalina Grubina, Jeffrey B. Doyon, Thomas M. Snyder, David R. Liu
Science, 2004, 305, 1601-1605.

“DNA-Templated Organic Synthesis: Nature’s Strategy for Controlling Chemical Reactivity Applied to Synthetic Molecules”

Xiaoyu Li and David R. Liu
Angewandte Chemie International Edition, 2004, 43, 4848-4870

“Highly Sensitive In Vitro Selections for DNA-Linked Synthetic Small Molecules with Protein Binding Affinity and Specificity”

Jeffrey B. Doyon, Thomas M. Snyder, and David R. Liu
Journal of the American Chemical Society, 2003, 125, 12372-12373

“Two Enabling Architectures for DNA-Templated Organic Synthesis”

Zev J. Gartner, Rozalina Grubina, Christopher T. Calderone, and David R. Liu
Angewandte Chemie International Edition, 2003, 42, 1370-1375

“Multistep Small-Molecule Synthesis Programmed by DNA Templates”

Zev J. Gartner, Matthew W. Kanan, and David R. Liu
Journal of the American Chemical Society, 2002, 124, 10304-10306

“Expanding the Reaction Scope of DNA-Templated Synthesis”

Zev J. Gartner, Matthew W. Kanan, and David R. Liu
Angewandte Chemie International Edition, 2002, 41, 1796-1800

“The Generality of DNA-Templated Synthesis as a Basis for Evolving Non-Natural Small Molecules”

Zev J. Gartner and David R. Liu
Journal of the American Chemical Society, 2001, 123, 6961-6963